The outcomes show evidence of both a proven action in the depression field and a real applicability potential in the other fields explored despite an obvious need of methodological refinement and replication to complement the existing accounts.
Many avenues for methodological refinement are identified.
Together, this methodological refinement may allow improving knowledge on fungi when designing proper strategies for landscape management.
However, quantitative limits for decreased fetal movement perform poorly for screening purposes, indicating the need for methodological refinement.
JB, JT and PN contributed to the conceptual and methodological refinement of the project; they also performed critical appraisal and editing of this manuscript.
While some data mining techniques have been adapted to the purpose, the state-of-the-art of research still needs both methodological refinements, the consolidation of a Knowledge Discovery in Databases (KDD) process, and, most of all, experimentation with real data.
We used these methodological refinements to characterise the effect of bleach-sedimentation on the safety, sensitivity, speed and reliability of smear-microscopy.
So despite the considerable efforts that have gone into methodological refinements of the RCT for example, trials may still reveal a skewed version of biomedical science.
However, some unexpected results required refinement in methodology.
Tier 2 was a refinement in 2000.
