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Moreover, no high quality methodological quality study [prospective cohort or randomized controlled trials (RCT)] has recently been published.
An in-depth analysis of the included publications with respect to the methodological quality (study design, data collection, endpoints chosen) and results showed that none of these publications had adequately investigated the age appropriateness of the medicine for use by older adults.
This was based on the methodological quality, study design and consistency of the study outcomes.
24 If the score was between 0 and 0.5, it was considered a low methodological quality study, and if the score was between 0.51 and 1, it was considered a high methodological quality study.
A systematic evaluation of published intervention and observational studies in humans considers the strength of the evidence in terms of study design, methodological quality, study sample sizes, relevance to the target population, replication of results, and the quantity and overall consistency of the evidence (FDA, 2009).
We will conduct a sensitivity analysis to verify the robustness of the study conclusions, assessing the impact of methodological quality, study design, sample size and the effect of missing data as well as the analysis methods on the result of this review.
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The confidence in these findings is strong, as results were based on high methodological quality studies without publication bias.
Instead we compared the results of the high and low methodological quality studies against each other, and did not find any contradictory results.
First, the studies varied in methodological quality and study characteristics.
Levels of methodological quality and study design were found to be variable.
Based on methodological quality, the study by Egol et al. was first excluded since they used a per protocol analysis.
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