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However, whether received citations reflect the methodological quality has been questioned [ 2].
The small number and heterogeneity of studies as well as the low methodological quality has limited the synthesis of findings and conclusions which can be drawn.
Because methodological quality has been shown to affect the results of trials in other areas of health care [ 17] it is likely that a lack of rigor has contributed to the inconsistent results.
Twenty-five studies on measurement properties of 15 generic self-reported instruments measuring health-related productivity changes have been systematically reviewed, and their methodological quality has been evaluated using the COSMIN-checklist in a best evidence synthesis.
The term "methodological quality" has evolved since its inception and involves the evaluation of the internal validity as well as the external validity of a given study [ 2, 3].
However, through the PROMOTION Registry data we have begun to show that PRO methodological quality has improved over time in RCTs in prostate disease, suggesting that the methodological challenges related to PRO logistics, design and analyses are no longer insurmountable [ 21].
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Studies of varying methodological quality have been conducted assessing this for reducing depressive symptoms [ 126].
Whether those patient characteristics or methodological quality have substantial influences on treatment outcomes deserves further studies in the future.
18 Their methodological quality had been assessed previously using the Jadad scale and Schulz approach to allocation concealment.
A multitude of studies of generally low methodological quality have reported the short- and long-term results of surgical management.
Whereas preliminary studies involved only single-case designs 32, 33 or single-group designs (with no control group), 34, 35 a number of studies of higher methodological quality have been published in the last few years.
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