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And, while economics presents its own methodological problems, the basic challenges facing researchers are not fundamentally different from those faced by researchers in other fields.
Previous studies have found that interferon beta does prevent disability, but the authors point out that many of them were marred by methodological problems — the use of control groups too ill to start medication, for example — that this study avoided.
Although precise age control is complicated due to methodological problems, the new data support formation of the valley fill during the late Pleistocene and its incision during the Holocene.
Due to these methodological problems the results should be interpreted with caution.
Gastric residues remain, despite methodological problems, the gold standard of feeding tolerance assessment [ 6]: an increasing volume is clinically relevant.
Because of methodological problems the data used to assess treatment needs for periodontal diseases have been of questionable value and are not comparable [ 2].
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To overcome this methodological problem, the activities (over a period of 6 months) of a real cloud computing IaaS environment were traced and the system parameters of each active physical and virtual resource were monitored.
Table 3 describes, for each type of methodological problem, the proposed adjustments, their feasibility, and costs according to the experts.
The present study, as well as other studies exploring incidence and causes of adverse events, has an important methodological problem: The identification of a medical error, a mishap or an adverse event is a subjective process.
But perhaps, the methodological problems of the study design are not the only possible explanation for the change in the data situation in the recent decade.
While public health specialists seek more effective and equitable response systems, the methodological problems and the expense of many conventional epidemiological approaches continue to limit the usefulness of pandemic surveillance, program monitoring and evaluation.
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