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A recent systematic review of trials of medication for TRD reported many conceptual and methodological problems relating to consensus on defining and assessing RD, or on adequate response to treatment.
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There are several methodological problems related to the estimation of intergenerational correlation in labor market outcomes.
Similar methodological problems related to sampling occurred in the study of Abdulla et al. (2009) based on autosomal SNPs; the authors found that haplotype diversity was strongly correlated with latitude (R 2 = 0.91, P < 0.0001), with genetic diversity decreasing from south to north.
However, there are critical questions on some premises of this mode which seem to shed light on some very basic methodological problems related with this approach – and which render the mode 1 approach extremely problematic even without regarding empirical evidence of its frequent inadequacy.
All the methodological problems related to QOL evaluation are somewhat magnified in the elderly.
Studies within this field have methodological problems related to the differentiation of alcohol/drug abuse and other mental disorders.
It is possible therefore that methodological problems related to drug analysis may have contributed to the differences between the earlier studies and the results of the present study.
This study was initiated as a consequence of methodological problems related to a cross-cultural survey involving cancer wards at three large hospitals in Copenhagen 2007-2009.
In general, we have less knowledge about vertebral fractures than about other fractures because of the methodological problems related to their verification.
Many factors play a role in making such demonstration difficult, reflecting a variety of methodological problems related with investigating breastfeeding in studies.
The aim of this paper is to initiate a debate on the methodological problems related to measuring patient delay in cancer studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com