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The ASD classification is to some extent an artifact of how autism was discovered, and may not reflect the true nature of the spectrum; methodological problems have beset Asperger syndrome as a valid diagnosis from the outset.
Although methodological problems have hindered the full power of these studies [13].
These methodological problems have been noted elsewhere [ 27].
Other knowledge gaps exist because methodological problems have constrained theory-testing.
In the red herring debate, several methodological problems have been raised (see. among others. [ 20, 21]).
A variety of methodological problems have been cited to explain these discrepancies.
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The methodological problem has already been discussed in the Introduction.
Another methodological problem has been distinguishing between blood and lymph vessels.
This methodological problem has been solved for the domain of genomic medicine by using graphical modeling.
The majority of observational studies on induction of labour have methodological problems, as has been highlighted in a review.
It also offers an overview of published equine pulmonary pharmacokinetic studies and considers the different sampling methods used and the influence existing methodological problems can have on the interpretation of data.
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