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Furthermore, methodological problems for example in the definition of gene sets may have impact.
In addition, new treatments in oncology offer particular methodological problems for cost-effectiveness analyses as (i) new agents often add a new element in a sequential treatment pathway and (ii) the standard comparator is either absent or highly variable across treatment centres and national healthcare systems.
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Then, there are surveys done by economic, social and cultural researches (artists' employment, artists' health care coverage and needs, the economic benefits of creative communities, and other related enquiries) that create a methodological problem for those looking for information.
However, this did not present a methodological problem for two reasons.
This is a methodological problem for studies whose target group are independent elderly persons.
Owing to the generally known methodological problem for assessment of androgens in PCOS, small sample size, and lack of any data on GLP1 effects on LH secretion, we cannot provide any firm conclusion about this observation.
Her research, linked below, addresses methodological problems of data sources for use in research on PAs and NPs, the effect of PA use on health resource utilization, and use and roles of PAs and NPs in various settings.
Black and Devereux (2010) present a recent survey of the evidence and methodological problems of the research available for developed economies, especially the United States.
Apart for the methodological problems of the original articles, other limitations of this analysis should be pointed out.
However, some methodological problems of the Kupperman Index were identified in this comparison (see [ 6] for details).
Several methodological problems exist, for example relating to competing events, non-random censoring, non-proportional hazards and dependent observations.
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