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However, this did not present a methodological problem for two reasons.
This is a methodological problem for studies whose target group are independent elderly persons.
Owing to the generally known methodological problem for assessment of androgens in PCOS, small sample size, and lack of any data on GLP1 effects on LH secretion, we cannot provide any firm conclusion about this observation.
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Furthermore, methodological problems for example in the definition of gene sets may have impact.
In addition, new treatments in oncology offer particular methodological problems for cost-effectiveness analyses as (i) new agents often add a new element in a sequential treatment pathway and (ii) the standard comparator is either absent or highly variable across treatment centres and national healthcare systems.
Another methodological problem typical for surveys was also observed in our study.
20 For each trial confirmed at high risk of bias after reassessment, two authors (AD, YY) independently identified, from the individual reports, the methodological problem(s) for each domain with high risk.
Black and Devereux (2010) present a recent survey of the evidence and methodological problems of the research available for developed economies, especially the United States.
Apart for the methodological problems of the original articles, other limitations of this analysis should be pointed out.
However, some methodological problems of the Kupperman Index were identified in this comparison (see [ 6] for details).
Such a methodological problem can hardly account for the existence of VO2/DO2 dependency only in one subgroup.
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CEO of Professional Science Editing for Scientists @ prosciediting.com