Under these circumstances, such linguists as Franz Boas (died 1942) were less concerned with the construction of a general theory of the structure of human language than they were with prescribing sound methodological principles for the analysis of unfamiliar languages.
On a normative level, it generates methodological principles for engaging in nonsexist science.
Here, we review the rationale for cognitive safety assessment, and explain several basic methodological principles for measuring cognition during clinical drug development, including study design and statistical analysis, from Phase I through to postmarketing.
The methodological principles for the non-inferiority trial design are described in the International Conference on Harmonisation guideline E10 [ 22].
Although there are biological explanations for differences in the clinical impact of CTCs and DTCs, different methodological principles for the detection of CTCs and DTCs, including the possibility for different sensitivity, might also contribute to incongruent results.
While the methodological principle of 'blinding' for minimising bias in randomised controlled trials (RCT) is widely debated and accepted, rarely is this depth of thinking applied to its correct handling with respect to design, reporting and analysis.
The study was deliberately designed for optimization of several important methodological principles of case control studies for risk factor analysis of antibiotic resistance, including control group selection and adjusting for confoundings such as time at risk, quantified antimicrobial selective pressure, severity of illness and comorbidity [16].
The first section describes the major methodological principles of clinical trial design required for a rigorous evaluation of the treatment benefit, as well as the various pitfalls or biases that could lead to erroneous conclusions.
The present work proposes a new controller synthesis framework, that is based on the methodological principles of Lyapunov design.
The methodological principles of this algorithm have been described.
