Very little is known about this, and there may be methodological obstacles to the empirical study of these experiences.
This has been the final methodological obstacle to studying the effects of concurrency.
Electromagnetic fields represent a methodological obstacle for epidemiologic studies and a quandary for risk assessment; there is need for more data.
However, recent developments of model-based methods of phylogenetic inference, molecular dating, and ancestral character state reconstructions [ 36, 37] should overcome at least some of the past methodological obstacles encountered in phylogenetic studies of mating type evolution.
Although a possible effect of exposure cannot yet be ruled out because of methodological obstacles in research primarily regarding exposure assessment and study design [ 14, 16], more recent approaches stress the importance of looking into the interaction of environmental, biological, psychological and social pathways [ 24].
However, these studies faced many methodological obstacles, including difficulties obtaining accurate measures of alcohol use patterns and problems controlling for confounding factors such as variations in the HIV strain, patient age, demographics, ethnicity, time since infection, comorbidities, medication side effects, and a host of environmental influences.
So, it seems the results from those Brazilian studies run into methodological obstacles that have produced biases in their research and hindered the analysis of their data.
In a short termist culture only costs are certain, but evaluating benefits is made even harder by multiple institutional and methodological obstacles.
Designers face methodological obstacles, however, when engaging with a future system with rapidly changing factors.
This is a difficult task, and not without substantial conceptual and methodological obstacles, as Ha et al. ([2012]) have shown that students have difficulty with tracings of their thinking and reasoning processes and may not be metacognitively aware of the origins of their thoughts and beliefs.
