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However, since most of the included variables are not significantly associated with this trajectory class, further research is necessary in order to define additional risk factors in an adequate methodological manner.
Note however that these faculties may develop their own questionnaires from their specific MSs in the same methodological manner as we did.
The review was structured in so far as a list of terms was defined and used to search electronic data bases in a methodological manner, but was not intended to be a systematic review with pre-defined data extraction forms, plans for data synthesis, quality assessment or specific selection criteria [ 19].
In view of the evidence of KIT mutations in GIST and their possible prognostic value (as well as their relation to imatinib therapeutic response) (Lasota et al, 1999; Heinrich et al, 2003), exons 9, 11, 13, 17 of KIT (which are those related to prognosis in the literature) were analysed in the same methodological manner.
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We found this necessary as our analyses differed from the original methods in technical or methodological manners (Supplement).
Furthermore, narrative literature reviews rarely consider, in a reproducible and meaningful manner, the methodological quality, degree of bias and therefore reliability of the primary studies that are cited.
However, before it can contribute to advances in this field in a comparative, reliable, and valid manner, several methodological issues warrant attention.
'Triangulating' methodological approaches in this manner could accelerate our understanding of the pathogenesis and prevention of diagnostic error.
First, this study was processed in a retrospective observational manner; thus, methodological deficiencies in assessing risk factors for MDR AB acquisition may lead to biased estimates or erroneous associations.
The differences in dendritic as well as in CD4+ and CD8+ T-cell profiles observed in different studies dealing with smoking mice may be accounted to the different methodological procedures (i.e. manner of smoking, time of exposure, number or type of cigarette) in use in different labs.
The article is written in a fair manner without big methodological bias.
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