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This research has some methodological limits: the sample was restricted, not randomized and was only representative of the patients admitted in surgical and medical wards of a single hospital in northern Italy.
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The study reported in this paper presents an evident methodological limit: the number of patients enrolled; in spite of the strong evidence in literature activity of the combination of gemcitabine and paclitaxel in metastatic breast cancer, the papers recently published in this field present the same limit.
46 Methodological variability limits the comparability of the data.
However, this methodological approach limits the interpretation of results to reporting on statistical associations rather than causality.
The lack of statistical significance for the effect of country, professional position and other sample characteristics is not strong evidence against their relevance, because the high between-study variance caused by methodological factors limited the power of the analysis (the regression had to control for three methodological factors before testing any other effect).
The methodological hurdles limit the scope for scenario development to inform policy on the Arab Spring Middle East.
However, consistent methodological shortcomings limit the generalisability of findings and currently preclude firm conclusions on effectiveness.
Methodological issues limiting the current body of work and recommendations for future research are discussed.
Even if the levels of shares in Argentina, Canada, New Zealand and the United States but not in Australia seem similar in the early 1930s (a commonality which is lost shortly afterwards), it is necessary to stress that several methodological issues limit the comparability of levels across countries (see Atkinson and Piketty 2007): the plot should be read in terms of dynamics and not levels.
Although several previous studies have addressed the issue of how chronic SSRI administration affects 5-HT synthesis, methodological considerations limit the interpretation of these results.
Some methodological aspects limit the generalization of the findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com