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Methodological limitations included small sample sizes limiting the power of the tests, and reliability of the effect estimation (hazard ratio+regression coefficients).
Methodological limitations included sampling and measurement biases, inadequate internal validity of measurement tools, poor specification of testing protocols and limitations in statistical analysis.
Other common methodological limitations included poor response rates, 19 22 35 40 41 inadequate description of the course 19 39 and/or inadequate reporting of results.
Methodological limitations included a long duration between cancer diagnosis and participation in retrospective studies, and samples biased towards higher socioeconomic groups.
Methodological limitations included the fact that all UMs, with a few exceptions, were registered in a general practice so this study did not represent the group of UMs without access to general practice.
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General methodological limitations, including sampling methodology, retrospective study design, and terminology, have been discussed previously [ 2].
Several methodological limitations, including preexperimental design approaches, limited control of confounders and small sample sizes burden this body of evidence.
Although the literature advocated early ambulation, the evidence base presented with a number of recurrent methodological limitations, including small sample sizes, lack of a control sample, and limited follow-up.
Existent research is plagued with methodological limitations including inattention to selection effects and reliance on mostly cross-sectional designs.
The current evidence base presented with a number of methodological limitations, including not randomising patients to group allocation, permitting allocation bias [23], and not blinding assessors to subject groups, therefore increasing the risk of assessment bias [24].
However, studies examining these associations have been subject to methodological limitations, including cross-sectional designs, retrospective measures, a lack of stress biomarkers, and the tendency to overlook momentary etiologic processes occurring within each day.
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