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The relationship between genotype and phenotype in severe forms of human genetic disease is often elusive because of methodological limitations in the quantitative evaluation of very low gene expression levels.
Several methodological limitations in the design make it necessary to evaluate the results with caution.
First, there are some methodological limitations in our soil handling, which might potentially bias the estimation of feedbacks (see Methods for mode detail).
Even though there are considerable methodological limitations in these studies [41].
It is important to note that there were methodological limitations in the aforementioned studies.
This may be partly explained by methodological limitations in the experimental setting.
There are methodological limitations in the present meta-analysis.
There are methodological limitations in relation to the questionnaire.
There are several methodological limitations in the present study.
There are some methodological limitations in this study.
There are several methodological limitations in the current study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com