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These results, demonstrating the limited sensitivity of LDSS, were considered reasonable because LDSS has a methodological limitation in that it fails to detect cis-elements of the position-insensitive type [ 7, 9].
Another potential methodological limitation in the way of collecting information on awareness of HAS guidelines and behavior in management of pediatric migraine patients may have implications regarding the interpretation of the results, since such data were obtained from a self-administered questionnaire by the GPs and may therefore be subject to recall bias.
The present study addresses this methodological limitation in the existing literature by using Medicare claims data to assess the extent of differences in MRI exams for Medicare patients among providers in orthopedic practices before and after their practice acquired onsite MRI capacity, compared to physicians in matched orthopedic practices without onsite MRI over the same period of time.
But the definition of infection is a methodological limitation in all similar studies.
However, the definition of infection has an inevitable methodological limitation in all similar studies.
This methodological limitation in recording the outcome variable could affect the temporality and causal interpretation of the results.
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Even though there are considerable methodological limitations in these studies [41].
It is important to note that there were methodological limitations in the aforementioned studies.
This may be partly explained by methodological limitations in the experimental setting.
Because of methodological limitations in the epidemiology studies, data are unreliable in terms of making any firm conclusions.
To investigate a certain set of methodological limitations in published anti vascular endothelial growth factor (VEGF) randomized controlled trials (RCTs).
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