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The study reported in this paper presents an evident methodological limit: the number of patients enrolled; in spite of the strong evidence in literature activity of the combination of gemcitabine and paclitaxel in metastatic breast cancer, the papers recently published in this field present the same limit.
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This research has some methodological limits: the sample was restricted, not randomized and was only representative of the patients admitted in surgical and medical wards of a single hospital in northern Italy.
This is a methodological limit of the remote sensing technique.
Of the 63 developing countries, 11 already had undernourishment levels below 5percentthethe methodological limit that can assure significance of the results different from zero) in 1990-1992 and have been able to keep it in that interval, and are therefore not the prime focus of the 2014 report.
Within the methodological limits of quantification, the effect of mass dose on the pharmacokinetics of F-florbetaben is minimal up to about 50 μg in healthy subjects.
However, consistent methodological shortcomings limit the generalisability of findings and currently preclude firm conclusions on effectiveness.
The methodological hurdles limit the scope for scenario development to inform policy on the Arab Spring Middle East.
Even if the levels of shares in Argentina, Canada, New Zealand and the United States but not in Australia seem similar in the early 1930s (a commonality which is lost shortly afterwards), it is necessary to stress that several methodological issues limit the comparability of levels across countries (see Atkinson and Piketty 2007): the plot should be read in terms of dynamics and not levels.
Although several previous studies have addressed the issue of how chronic SSRI administration affects 5-HT synthesis, methodological considerations limit the interpretation of these results.
Some methodological aspects limit the generalization of the findings.
11 However, some methodological differences limit the comparison of results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com