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Beyond methodological issues on the use of one or other marker for molecular epidemiology or the most appropriate model for phylogenetic inference, the application of Evett and Weir's [ 15] procedure and the extension that we propose in this work are highly recommendable.

Together, these measures should have served to reduce the influence of methodological issues on the models, and improve their integrity.

The main aim of the present study was to do an update on studies on headache epidemiology as a preparation for the multinational European study on the prevalence and burden of headache and investigate the impact of different methodological issues on the results.

We also discuss the effects of homoplasy and methodological issues on the results.

In order to choose an appropriate guideline we examined the methodological issues on guideline evaluation and implementation strategies and we conducted a systematic search and evaluation of existing guidelines on diabetes care [ 13- 15].

The design of this study targeted several clinical and methodological issues on TNF blocker dose de-escalation, including how to taper the TNF blockers, the satisfactory control condition, how to define flare, implementation in clinical practice, and the choice of the non-inferiority margin.

Similar(54)

This study addressed methodological issues of epidemiologic studies on venous thromboembolism (VTE) to show how design decisions can affect the results.

22– 24 Considerable research focused on methodological issues of NMA has been published in recent years; however, a limited number of simulation studies have been conducted.

Reported barriers to the use of QoL measures in clinical practice were related to time constraints (8.7%) but also to doubts on methodological issues of QoL (30.7%).

In this context, the emphasis is on methodological issues and on different stages of indicator operationalization.

After Davidson, the consensus has been that the philosophical question raised by the action/event distinction is not conceptual but metaphysical: "how can action explanations co-exist alongside event explanations?" Discussions of the action/event distinction have accordingly tended to focus not on methodological issues but on the problem of causal over-determination.

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