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These methodological issues have generic resonance in the reconstruction of urban landscapes.
Some of those methodological issues have been addressed in follow-up experiments (Soon et al. 2008; Fried et al. 2011).
However, several methodological issues have been raised concerning Lac visibility in MRS as well as Lac dynamics following PS, which are related to low Lac concentrations under different experimental conditions [37, 38].
While epistemological and related methodological issues have been at the forefront of discussions about animal consciousness, philosophical attention to consciousness in the analytic tradition over the last several decades has focused on metaphysical questions about the nature of phenomenal consciousness and its fit (or lack thereof) within a naturalistic framework.
This latter assumption is problematic: according to [13], methodological issues have not been fully resolved regarding the potential underestimation of long-term variability in methods such as climate-field reconstruction or proxy scaling.
Some methodological issues have to be considered.
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Gastric tonometry was made commercially available before all of the methodological issues had been resolved and this resulted in negative press.
An emerging literature on the effects of gene-environment interactions on behavioural disorders and an outline of the methodological issues has recently been reviewed [ 28].
While naïve application of GC to fMRI data is unlikely to be informative, careful consideration of the methodological issues has permitted some useful applications that have produced testable hypotheses.
As the volume of evidence was perceived to be small, an aim of the review was to include as much evidence as possible, regardless of method, several methodological issues had to be dealt with.
87 In a review of its effectiveness, it was concluded that the extent of benefits were not clear, 13 while studies which have reported on the follow-up long term effects of glatiramer acetate, 87, 88 have also been confronted with methodological issues, which have tended to cloud the quality of these studies.
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