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However, with all of methodological issues considered, results must be interpreted with caution.
Subgroup analysis of other methodological issues considered in the risk of bias assessment could also be analysed as sources of variation that could be included in future updates of this review, such as the purposive nature of the co-morbidity measurement, the influence of sponsorship from the gambling industry, the use of a comparison group, and concurrent treatment restriction.
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Several methodological issues were considered when designing EXCITE.
There are some methodological issues to consider with this study.
There are some methodological issues to consider.
Third, there are significant methodological issues to consider.
There are a number of methodological issues to consider when interpreting these data.
However, our in-depth assessment of 20 recent IMPF articles identified that the IPD approach itself has many challenges, with numerous logistical and methodological issues to consider, as summarised in Table 2.
However, thermodilution and echocardiography have both been validated and this methodological issue was considered as acceptable in a previous report [ 18].
All other methodological issued were considered as important as for the full trials, such as trial registration, randomization, hypothesis testing, statistical analysis and reporting according to the CONSORT guidelines.
There are several methodological issues to be considered in this study.
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