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Furthermore, the current availability of novel antigenic preparations (recombinant, highly purified extracts, circular plasmids and synthetic oligonucleotides), along with other methodological improvements, has led to the production of new generation immunoassays that are able to detect anti-dsDNA only of intermediate and high avidity [49].
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Recent methodological improvements have facilitated a greater appreciation of the importance of fungi in many aquatic systems, yet a conceptual framework is still missing.
The reason it is hard to make the census more accurate is because methodological improvements have already lifted accuracy nearly as high as it seems able to go, said David Freedman, a statistics professor at the University of California at Berkeley.
Furthermore, many methodological improvements have been made over the past decade to allow for increased efficiency of deorphanization and validation of ORs.
Although virtually every dendrogeomorphic paper is still based on the concepts established by Shroder (1978), important methodological improvements have been achieved in the field ever since and more particularly over the last decade.
Several methodological improvements have been suggested to infer gene regulatory networks based on GGM [ 121- 123].
During the last few years, several methodological improvements have contributed to increase the robustness of 2-DE workflows.
There have also been methodological drawbacks in the studies that have examined the volume-effectiveness relationship, and several suggestions for methodological improvements have recently been pointed out [ 11- 13].
Furthermore, although trials have shown some recent methodological improvements, most have been underpowered to detect clinically important changes in glycated haemoglobin (HbA1c) levels.
Additionally, we discuss methodological improvements that have enhanced the accessibility, efficiency, and robustness of cell-free approaches.
As such, they are a methodological improvement that has generally gained a positive reception among philosophers of biology (e.g., Sterelny and Griffiths 1999).
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