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Clinical and methodological heterogeneity will be judged according to the data recorded on the extraction form.
Clinical and methodological heterogeneity will be evaluated by noting differences in the distribution of important participant factors between trials and different factors in the trial design.
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Limiting the methodological heterogeneity across studies will be of the utmost importance in further research in the treatment of SE: investigators should adopt uniform definitions of SE and its different stages, provide individual patient data, and report their results clearly and explicitly.
Limiting the methodological heterogeneity across studies will be of utmost importance in further research in the treatment of SE: investigators should adopt uniform definitions of SE and its different stages, provide individual patient data, and report their results clearly and explicitly [ 62].
If clinical and methodological heterogeneity is present, we will perform subgroup analyses.
If considerable methodological heterogeneity is present, subgroup analyses will be performed through comparing the findings between studies of low and unclear or high risk of bias.
If considerable methodological heterogeneity is present, subgroup analyses will be performed by comparing the findings between studies of low, unclear, and high risk of bias.
A quantitative synthesis of effects will not be attempted because of substantial methodological heterogeneity among studies.
On the basis of a synthesis of methodological quality estimation for each study included, the findings will be available for a further subgroup analysis to explore potential methodological heterogeneity.
If clinical and/or methodological heterogeneity of the included studies proves to be extremely high, a qualitative rather than quantitative synthesis of the evidence will be performed [ 33, 36].
No quantitative data synthesis was allowed due to methodological heterogeneity.
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