This study showed promise but clearly suffered from major methodological flaws in study design, and so the conclusions drawn are subject to careful scrutiny and review.
Data available so far show that telemedicine solutions for diabetes care are feasible and acceptable, but their effectiveness in improving A1C, reducing costs while maintaining A1C levels, or improving other aspects of diabetes management is not fully clarified because of methodological flaws in study design (10, 11).
A general methodological flaw in studies which analyze the polymorphism in consecutive series of patients treated with the same drug is that the predictive value of these polymorphisms with respect to drug sensitivity cannot be discriminated from the prognostic value.
Common methodological flaws in the studies were their small sample size and an inappropriate description of the study design.
There is insufficient evidence as to whether acupuncture is more effective than other modalities of treatment such as medication, which might be because of the small number of trials as well as inadequate reporting or methodological flaws in some studies.
Their results were limited by the small sample sizes and methodological flaws in the studies reviewed.
Moreover, this failure may be explained in part by the methodological flaws in animal studies, eventually leading to a systematic bias which might generate incorrect conclusions about efficacy of a drug or a compound [ 11].
Several studies taking a general view of the situation conclude that their benefit is evidence-based [ 29, 30], while others point to methodological flaws in the studies and take a very critical stance towards the use of the EB concept in this context [ 17, 31].
The methodological flaws in the study led an independent auditor appointed by the journal that published the study to describe it as "a non-scientific study" and conclude that it should not have been published.
Despite numerous methodological flaws in previous study designs and the lack of validation in primary care populations, clinical tests for identifying acromioclavicular joint (ACJ) pain are widely utilised without concern for such issues.
Finally, whilst there were methodological flaws in many of the studies, the population recruited was clearly defined in all but six and was representative of typical acute femoral and tibial fractures in the final review.
