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The EFSA Panel justified this opinion based on supposed methodological errors in [3].
In this communication, we discuss this point and some other methodological errors in the formulation.
Seven papers (7%; 95% CI 3 14%) reported clear methodological errors in the analysis.
Of course, it is not possible to enumerate all the methodological errors in this analysis; some errors, such as disregarding the underlying phylogeny for the 60 human genomes, and treating them as independently derived, will not be commented upon.
Research from 1999 states there are methodological errors in prior papers and very few large-scale studies prior to this date, destabilising the validity and reliability of research from the papers written before 1999.
One important reason for such discrepancies is the relatively large number of individual and methodological errors in linguistic datasets 19; this is reflected by numerous cases of wrong translations, wrong homology assessments (incorrect identification of cognate words), and undetected cases of lateral transfer (borrowing) 17, 18.
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It also suggests that methodological error in rate estimation is equally distributed around the mean estimated rate.
In contrast, our results show an increase in mean rate variation as branch length increases (Figure 2) and we attribute this to methodological error in branch length estimation.
Therefore, an important methodological error in the cystatin C measurements was considered improbable.
12 28 In the absence of a universal calibrator for cystatin C, the choice of the cystatin C measurement method is of crucial importance 29 and can importantly affect the performance of a cystatin C-based equation that is not derived by using the same calibrator and method, resulting in a significant methodological error in GFR estimations.
It also rules out methodological errors, if any.
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