21 Conflicting results may be due to methodological discrepancies in the design of the studies and in the assessment of RLS and of neuropathy, and variations in etiology of neuropathy between cohorts; in addition, it should be considered that, as polyneuropathy is usually an evolutive condition, the appearance or disappearance of RLS may be related to different phases of the disease.
As discussed in the accompanying Part I review 6 and elsewhere in the present review, the French RCT should not be pooled in an MA with the other RCTs because of methodological discrepancies.
Finally, in light of the methodological discrepancies encountered within this literature, we conclude with a series of recommendations on how to optimally detect valid, robust, and consistent effects in healthy populations that should aid future assessment of neuroenhancement.
Validation of model estimates using in situ measurements provides vital information on model performance [6,53,54], even if scale differences, sampling strategies and methodological discrepancies in data collection reduce comparability.
The reconciliation of results from different studies using different estimation procedures depends on finding out and taking potential methodological discrepancies into account before comparing the data (see e.g. [3], [8]).
Selected studies presented several methodological discrepancies.
We argue this might be due to the methodological discrepancies between the 2 studies.
Hence, despite extensive research into the utility of cfDNA and DNA integrity index as diagnostic and prognostic biomarkers in malignancy, the methodological discrepancies have dictated that the tests have remained as research tools.
Apart from methodological inadequacies, the discrepancy of the results of previous studies might be attributed to the specific kinematic and dynamic conditions associated with each individual exercise.
The mentioned discrepancies of previous results might rely on several methodological factors, including small sample sizes, differences in time points of the cycle, or lack of noncycling control samples.
