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This problem is compounded by methodological discrepancies within the literature, and reliance on psychometric tests designed to detect cognitive effects in ill rather than healthy populations.
Validation of model estimates using in situ measurements provides vital information on model performance [6,53,54], even if scale differences, sampling strategies and methodological discrepancies in data collection reduce comparability.
Finally, in light of the methodological discrepancies encountered within this literature, we conclude with a series of recommendations on how to optimally detect valid, robust, and consistent effects in healthy populations that should aid future assessment of neuroenhancement.
The reconciliation of results from different studies using different estimation procedures depends on finding out and taking potential methodological discrepancies into account before comparing the data (see e.g. [3], [8]).
Finally, Although most of the studies adopted similar real-time PCR method (Taqman assay) to measure the copy number of CCL3L1 in samples, minor methodological discrepancies of different studies as differences in DNA concentration and differences in primer and probe dye chemistry might have affected the results [39].
Selected studies presented several methodological discrepancies.
Similar(43)
The estimated age of the bottleneck for the pair of clades, 2.30 My, predates the estimated divergence time of all extant L. boeticus 1.5 Mya (Fig. 2B), suggesting methodological discrepancy between the methods used to date divergence times and those used to estimate time since expansion.
Two reviewers independently assessed methodological quality; discrepancies were resolved through consensus or by third party adjudication as required.
Still for discrepancies methodological and study population difference, and the existing risk factors variation might be responsible.
The authors should briefly discuss these findings and offer an explanation for the discrepancy (methodological or biological) in results.
Apart from methodological inadequacies, the discrepancy of the results of previous studies might be attributed to the specific kinematic and dynamic conditions associated with each individual exercise.
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