3, Since the quantification of the intensity of contacts is characterized by methodological difficulties (the number of contacts does not always turn into quality), I used the scores, based on available information: 0 point no ties 1 point connection exists; however, financial information is not provided or the total annual turnover of affiliated companies is less than ten million RUB.
Given the background of methodological difficulties, the findings of our study should be interpreted with caution.
As suicide research has to deal with specific methodological difficulties the design and development of study protocols needs to be cautious.
None of the HTA agencies included intangible costs in the denominator, reflecting that this cost type is seldom used because of methodological difficulties (the same cost influences the numerator as well as the denominator in the analysis).
For cultural reasons and because of methodological difficulties, the association between type 2 diabetes and sexual function in women has been studied in fewer objective studies than the effects of diabetes on sexual function in men [ 4].
Despite conceptual and methodological difficulties, the assessment of (HRQoL) can assist in caring for chronically ill patients and the most common measuring approach is using descriptive psychometric instruments that describe health status in a number of different areas.
Our inability to measure, because of the intrinsic methodological difficulties, the various gene-gene and gene-environment interactions and the way they affect chromatin and DNA means that over this timescale our disease risk assessments based on DNA sequence information will remain, in an important sense, incomplete.
An important methodological difficulty of the present study is the retrospective nature of data collection.
The neural invariances, in terms of the locations and activation amplitudes of common diagnostic voxels, emerged despite the methodological difficulty of normalizing the morphological differences among participants.
The chief methodological difficulty has been the increasing rate of disruption of these runs over time by chromosomal rearrangement.
