Sentence examples for methodological difficulties such from inspiring English sources

However, such tests are not always feasible in routine due to methodological difficulties such as a long incubation period, prolonged cellular purification procedures, and absence of standardization.

The methodological difficulties such samples present, particularly in proteomic work, should not be underestimated (Ray et al, 2011).

Methodological difficulties, such as a lack of suitable control interventions 9 and failure to maintain complete blinding to allocation, can mean that factors such as increased attention, socialisation or motivation could contribute to observed changes, or that participant and investigator placebo effects may operate.

The two year results highlight many of the methodological difficulties of such an approach, including the inherent difficulty with historical comparators, and the major uncertainties around the interpretation of the current results.

Extending this initial work through the use of observation methods may add to our understanding of consultations, though the methodological difficulties inherent in such a study should not be underestimated.

Strength of findings may be limited by the uncontrolled nature of the studies, but given the methodological difficulties of evaluating topics such as educational impact and doctor performance, 38 descriptive and observational studies can still provide useful information.

Such methodological difficulties can be overcome in trials of laser acupuncture as it is possible to successfully blind both participants and clinicians by using specially designed laser machines [ 24].

We believe this conclusion to be unsound and use this study as an example to illustrate the methodological difficulties which may arise during such international comparisons.

Both these reviews focussed on cancer and both groups of authors agreed on the paucity of good quality evidence, considering the reason for this to be the methodological difficulties inherent in trying to make such evaluations in an ethical manner, with full and informed consent while maintaining comparable trial and non-trial groups.

Although prospective studies are clearly desirable in delineating the role of early environment in the development of later-life aggressive behavior, such investigations face daunting methodological difficulties.

Such evaluations are fraught with methodological difficulties, which to our knowledge have not been explored in the literature.