Exact(1)
However, such experiments are technically more demanding and there are unique methodological difficulties for their use in the context of neurobiology and the study of central nervous system disorders.
Similar(59)
For example, the decision of the number of clusters is not always easy and is an intrinsic methodological difficulty for almost all clustering tools in real practice.
A way to overcome the ethical and methodological difficulties of using patients for as many as three examinations is to spread them out over several days, as in the studies of Ljungquist et al. [ 4] and Horneij et al. [ 13].
Diagnosis of pancreatic exocrine insufficiency (PEI) is hindered by methodological difficulties of pancreatic function tests.
However, some methodological difficulties of the study need to be discussed.
Several technical and methodological difficulties exist for investigators to unravel this process in myelinated axons – a complex two-cell unit.
Searching for such loci systematically at a genome-wide level will require extremely large-scale sequencing, for which the technology is currently being developed and which will present us with new statistical challenges and methodological difficulties pertaining, for example, to the functional study and classification of identified variants.
Moreover, potential departures from theory are generally suspected to result from methodological difficulties associated with, for example, phylogenetic estimation per se, incomplete or missing taxonomic accounts, ambiguous character state coding, and/or subjectively chosen character transformation weights [ 17, 24, 25, 30, 31].
Most of the trials, however, have been criticized for methodological difficulties, particularly lacking appropriate control conditions and number of patients included.
Hence, 20 patients were enrolled in this study in order to allow for any methodological difficulties that could lead to exclusion from the study.
A systematic review of mental health in refugees and displaced people in Syria and surrounding countries (including 13 studies) found high and rising levels of mental distress but also highlighted methodological difficulties in obtaining accurate prevalence figures for mental illness.
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