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This might be explained by methodological differences, like site differences or a different protocol.
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Heterogeneity can be caused by study-level characteristics like methodological differences in design or conduct of the study (bias), between-study differences in defining test positives (different cut-points), or other design-related characteristics [ 30, 31].
Methodological differences are also a likely factor.
The study by Singareddy et al. also included other important methodological differences which may explain divergent results, like different population at risk (they included subjects with poor sleep), different way to diagnose migraine (self rapport according to 'physical based diagnosis'), and number of study participants (1246 versus 19,271 in the present study).
Thus, along with different diagnostic criteria, it is likely that other methodological differences play a role.
The factors like setting and methodological differences, clinical and socio-cultural factors might be responsible for this inconsistency.
We would like to make comparisons with other countries, but there is no point in doing so when methodological differences may be the explanation of any differences [13].
"Any relative difference in effectiveness between S.S.R.I.'s is probably best explained by methodological differences and not by specific differences in the medications," Dr. Emslie said.
So the methodological differences are showing up in a big way this year.
Despite the various ideological and methodological differences with Richard Posner, Akerlof and Shiller's fundamental view of how capitalism should work is similar: "What allows capitalism to function is the regulations," they write.
This may depend on methodological differences.
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