The slightly lower fraction of CCND1-amplified cases may be due to all patients being ER-positive or due to methodological differences and different cutoff points for defining amplification between studies.
Caution is recommended when interpreting and comparing results of different studies, as methodological differences and challenges are substantial (cf. introduction).
Despite the methodological differences and application of different insulin pumps (the STAR 3 pumps were sensor-augmented), results confirming the overall benefit of CSII seem surprisingly convergent.
Although the two indicators take a broadly similar approach, there are a number of methodological differences, and they were developed for different purposes.
As recently indicated by Tao and colleagues, studies are needed that use the same methodology simultaneously in both adolescents and adults, to overcome methodological differences, and correct interpretation of the age-dependency of results [ 104].
In addition, the difference in published reports may be attributed to the numbers of samples tested, methodological differences, and the sensitivity of methods used, such as use of different primer sets.
This in part is due to the different definitions ascribed to GISA and hGISA that are subject to methodological differences and variations in (clinical) breakpoints and cut-off values [ 12, 13].
"Any relative difference in effectiveness between S.S.R.I.'s is probably best explained by methodological differences and not by specific differences in the medications," Dr. Emslie said.
The factors like setting and methodological differences, clinical and socio-cultural factors might be responsible for this inconsistency.
Despite the methodological differences, musculoskeletal and cardiovascular diseases were among the main causes of disability in all previous studies [ 3, 10, 11, 13- 15, 32, 33].
A significant statistical heterogeneity reflects clinical and methodological differences across studies, and higher temporal variabilities among PT measurements over time, related to unstable excitability levels.
