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If we add to this flagrant methodological deviation the regrettable inconstancy with which many of the comments about these Member States are made without sufficient objective and appropriate grounds (as the rapporteur herself admits), we have a set of basic reasons why in accordance with its own premises, the Swiebel report must be rejected.
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Potential ecological and methodological explanations for deviations from the model suggest that spatial and temporal heterogeneity are important drivers of the structure of these large networks.
However, our meta-analysis also has many limitations, such as the clinical and methodological heterogeneity, protocol deviations, sparse data, and concerns regarding small trial bias.
The fundamental difference is methodological.
HWE should be investigated in the individual studies, since deviation from HWE may reflect methodological problems, such as genotyping error, population stratification, or selection bias (30).
This approach has striking conceptual and methodological simplicity, and in the near future deviations in the distribution of allelic imbalances along exons might be used to infer the extent of the sample's heterogeneity.
1568 subjects (532 men, 1036 women, mean age 45 and standard deviation (SD) 13 years) were evaluated in this cross-sectional, methodological study.
Deviations from HWE in the control group may indicate significant methodological flaws including selection bias, population stratification and genotyping errors [57].
Rating from the methodological quality reviews ranged from 25%to91%1% of available points, with an average ± standard deviation rating of 52 ± 20%.
The studies were of variable methodological quality, ranging in overall score from 5 to 19 (maximum = 28) with a mean of 15.8 [standard deviation (SD) = 3.6] (Table 2).
CVtP is the CV derived from the mean and standard deviation of a study and includes true between-subject variation, an element of within-subject variation and methodological errors.
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