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Meta-analysis was not attempted due to heterogeneity; the studies differed considerably in methodological design, risk factor assessment and disease groupings.
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Owing to the insufficient clinical data, poor methodological design and high risk of bias, it is difficult to draw a definite conclusion regarding the effectiveness and safety of JLD for EH.
Although the most rigorous methodological designs for assessing risk compensation behavior may be unavailable due to ethical flaws, several strategies can help investigators identify potential risk compensation behavior during Phase II, Phase III, and Phase IV testing of new technologies.
This study had a methodological design.
A pilot, descriptive, methodological design was used.
The experts oriented the methodological design Fig. 1.
They were heterogeneous in methodological design.
Some of the studies at high risk of bias were initially designed to assess aspects of PCC other than its effectiveness in improving maternal and fetal outcomes, hence the poor methodological design when assessed with the NOS [ 16, 22, 30].
Four reports did not clearly specify the methodological design.
KR contributed to the methodological design and analyses.
No restrictions were placed on publication year or methodological design.
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