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However well a manuscript is written, it cannot hide the methodological defects of a poorly designed study.
Another reason could be methodological defects.
For instance, some studies present methodological defects (small samples, short following-up periods, compliance not always high).
Some studies suffered from methodological defects and were at high risk of bias [ 17, 18, 21, 22].
The 11 included trials were of variable methodological quality; the major methodological defects being the failure to provide details of allocation concealment, addressing the missing data etc.
This may be because all relevant RCTs were limited by methodological defects, including inappropriate sample size, variability of acupuncture and sham protocols, and missing information.
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As this evidence is based on studies that presented some kind of methodological defect, and as various types of expensive multidisciplinary rehabilitation are commonly employed, there is an obvious need for high-quality trials to be carried out in this field [ 13].
This work not only helps to understand the electrocatalytic influence of the co-generated MoO3 species in MoS2, but also presents a methodological improvement in designing defect-rich, oxygen incorporated and holey MoS2 nanosheets for highly efficient hydrogen evolution.
This implies that either there is overestimation of dentinal defects due to the methodological limitations of in vitro studies or not all of the defects propagate into ROFs.
We did not find altered specific-to-nonspecific [123I]FP-CIT binding ratios in patients treated for a large sellar tumor giving rise to visual field defects, although a number of methodological issues preclude a definitive conclusion.
In designing the computerized system for evaluation of IONDT visual fields, we encountered several methodological issues that could have influenced definitions of defect classification and/or change.
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CEO of Professional Science Editing for Scientists @ prosciediting.com