However well a manuscript is written, it cannot hide the methodological defects of a poorly designed study.
Another reason could be methodological defects.
For instance, some studies present methodological defects (small samples, short following-up periods, compliance not always high).
Some studies suffered from methodological defects and were at high risk of bias [ 17, 18, 21, 22].
The 11 included trials were of variable methodological quality; the major methodological defects being the failure to provide details of allocation concealment, addressing the missing data etc.
This may be because all relevant RCTs were limited by methodological defects, including inappropriate sample size, variability of acupuncture and sham protocols, and missing information.
Although a systematic review of acupuncture for neurogenic bladder after SCI was published in 2013, the result of the review was inconclusive due to the serious methodological defects of the included studies and the small number of trials assessed in meta-analyses.
2) Multiple methods and different frequencies of postoperative delirium screening across the studies were another source of heterogeneity [ 1]. 3) For the same intervention, the dose and duration varied greatly among studies and this might account for different effects [ 70]. 4) Application of the scoring system developed for this study revealed methodological defects in some studies.
This work not only helps to understand the electrocatalytic influence of the co-generated MoO3 species in MoS2, but also presents a methodological improvement in designing defect-rich, oxygen incorporated and holey MoS2 nanosheets for highly efficient hydrogen evolution.
This implies that either there is overestimation of dentinal defects due to the methodological limitations of in vitro studies or not all of the defects propagate into ROFs.
