In conclusion, our reevaluation resolves the methodological contradictions between Ikegaya et al. (2004) and Mokeichev et al. (2007), but demonstrates the validity of our previous conclusion that spontaneous network activity is non-randomly organized.
The overall quality of the information about menopause (from professional and non-professional sources) is poor and it has clear methodological flaws, contradictions and conflicts of interests (economic and professional) [ 6].
Among methodological differences, the contradictions between the studies may have been caused by one important bias: most of the previous studies employed a cross-sectional design.
The cause of such contradictions may result from methodological differences, related to differences in design, populations studied and also probably due to the fact that we have adjusted for intensity and duration of pain.
This apparent contradiction may be attributed to methodological differences, as imaging studies usually sample a broader brain area and do not exclude circuit-dependent inductions during measurement, whereas molecular studies are more localized.
However, this apparent contradiction can perhaps be attributed to methodological differences.
The results presented in that study provide evidence indicating a lack of methodological precision and accuracy, and involving inherent technical contradictions.
Our findings are generally in good agreement with previous in vitro characterizations, and what contradictions exist are likely due to methodological differences.
These contradictions arise partly as a result of methodological and disease detection/diagnostic issues.
These contradictions in gene expression direction may arise from methodological differences or from regulatory and feed-back mechanisms similar to the above mentioned discordance for the "E2 or E2/P systemic" gene set.
As the present findings are in contradiction with the existing literature, larger prospective, controlled investigations with a rigorous methodological design are necessary.
