Exact(2)
Despite this trial's significant results, some methodological constraints such as its small sample size (N = 10) and large number of outcome measures limited the generalisability of its findings.
This analysis also served as a control to clarify that the generalization of multi-voxel patterns is not decreased due to methodological constraints such as differences in realignment of fMRI data from the different days.
Similar(58)
Methodological constraints associated with problems of observing in vivo vascular flow, such as the lack of transparency of tissues, have made it difficult to assess vascular reactivity directly within the hindlimb, as with other intravital organs (heart, lung and brain).
Although there are obvious methodological constraints to the measurement of some outcomes (for example, long-term outcomes such as admission to residential care), it is nonetheless important that future trials of cognition-based interventions routinely measure and report outcomes other than direct cognitive ones.
Gatesy et al.[ 57, 58] compared the two approaches and brought attention to the methodological constraints of the supertree approach e.g. (i) source data which contain non-cladistic characters such as taxonomy lists, (ii) duplication of homologous characters or (iii) robustness values of tree nodes that are difficult to interpret.
These methodological constraints mean that only a small part of the species' range can be surveyed; for example, until 2004, such surveys for orangutans in the Indonesian part of Borneo covered an estimated 20 25% of their total range [11].
Such difference between mRNA expression and protein level may be due to several biological and methodological constraints that play a role when comparing mRNA to protein levels [ 46].
Such rolling circle intermediates (RCIs) of satellite eccDNA molecules were not, however, observed due to the methodological constraints of 2-D electrophoresis [ 42].
Conclusions are limited by methodological constraints.
The reasons and implications of this choice are discussed further (see "Methodological constraints").
Another telling factor that we could not include, given our methodological constraints, was the existence of domestic partner registries.
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