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Methodological considerations are a major concern when carrying out molecular epidemiological studies of diagnostic markers to avoid errors that increase the potential for bias.
Lower quality is defined as, e.g., smaller populations, relying on local case studies/in-house experiences and no explicit methodology or theoretical base, and higher quality is defined as, e.g., the methods are explained, analytical tools are provided, methodological considerations are included and theoretical references are used.
Heterogeneous methodological considerations are the main explanation of this conflict.
Several methodological considerations are of interest to discuss.
For HPSR + A units in other African universities and other continents wishing to conduct such an assessment, a number of methodological considerations are proposed.
Here, these methodological considerations are illustrated by examples from peer-reviewed literature and from a locally developed study to illustrate how some of the challenges can be addressed.
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Furthermore, methodological considerations were proposed for improving the reproducibility of these outcomes.
Details of methodological considerations were as described previously [35], [36].
In order to acquire reliable images of metabolites in and around cancers in vivo, several lines of methodological consideration are necessary.
Another methodological consideration is the intervention starting at diagnosis.
Another methodological consideration is the use of pentobarbital anesthesia.
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