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To be valid, a laboratory's reference interval should account for differences in chemical methodology and reproducibility of that method, but statistical methodological concerns are also of importance.
Interestingly, methodological concerns are acknowledged, but they are not given prominence in the reviewed studies.
While methodological concerns are usually acknowledged in such papers, they are not given prominence there, and there is a lack of cross-cutting methodological work addressing these issues.
Studies were not excluded due to quality issues; however, methodological concerns are presented as part of both the Results and Discussion sections.
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The methodological concerns were sorted out into different themes; related to the research procedure, logistics and practical matters.
The results were further discussed and methodological concerns were considered, such as the low BAC achieved, practice effects, and insensitivity of tasks.
Two studies that did address all of these methodological concerns were those of data on myocardial infarction related mortality, which found a detrimental effect of heat 20 or of both heat and cold.
Of methodological concern are the number of small trials, suspicions of outcome reporting bias 25 within the trials, 26 and the use of a crossover design, the suitability of which has been questioned because of the impact on the circadian timing system outlasting drug washout periods.
A second, related factor mitigating this methodological concern is that our follow-up period is measured from the time of the final FMR decision, when beneficiaries no longer have a reason to hold down their earnings in the anticipation of eventual program receipt.
A final methodological concern is that the results may be partly due to the limited spatial resolution of fMRI, and in particular to partial volume averaging.
Another methodological concern is validity of the results [ 30].
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CEO of Professional Science Editing for Scientists @ prosciediting.com