These methodological circumstances may explain the apparently contradictory results from other studies.
As yet, drawing conclusions from such studies is impaired by several circumstances, such as methodological limitations of each study, heterogeneity of the criteria for assessing and estimating parental and children's exposures (and assessment of the role that non differential misclassification might have in "negative" studies), heterogeneity in the criteria for selecting controls publication bias.
We consider our comprehensive methodological approach to be particularly useful in circumstances such as this, when substantial uncertainty exists regarding not just the range of possible solutions to a given health problem, but also regarding the nature and presentation of the health problem itself.
Under these circumstances, such linguists as Franz Boas (died 1942) were less concerned with the construction of a general theory of the structure of human language than they were with prescribing sound methodological principles for the analysis of unfamiliar languages.
Under the circumstances, such niceties seemed a trifle bizarre.
They favour certain circumstances such as locative circumstances and circumstances of quality and degree manner.
Depending on your circumstances, such a plan could make sense.
Under most circumstances, such an assumption cannot readily be tested.
Such exposure circumstances represent a challenge to epidemiology, because of methodological issues such as limited power to detect small risks, exposure misclassification, and residual confounding.
It is true that this approach, too, comes with serious methodological caveats, such as verifiability, selection bias or observer bias.
