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A number of methodological challenges need to be answered.
No matter how good the system is, major methodological challenges need to be overcome to evaluate such systems in a rigorous and clinically relevant way.
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This article examines briefly contemporary research foci on the limiting factors to sports performance, the informational basis for expert performance, and the social/developmental structures important for the emergence of sport expertise, and considers some of the methodological challenges that need to be addressed to progress the field.
Researchers face a number of methodological challenges and need to make several choices in the design and conduct of pragmatic trials.
Our representations are provided as illustrations of the principle of how genotypic risks can be adjusted according to clinical status, and should be interpreted in light of the numerous methodological challenges that need to be addressed.
However, the differences in the type of horizontally transferred sequences between prokaryotes and eukaryotes and in the quantity of DNA to be investigated raise specific methodological challenges that need to be addressed to obtain a broader picture of genome-wide HT dynamics in eukaryotes (de Carvalho and Loreto 2012).
The resultant sampling design, however, raised a number of methodological challenges, including the need to account for spatial and temporal variability in measures collected during different weeks, and the need to account for home site characteristics and other residential sources which may obscure the true traffic-concentration relationship.
Methodological challenges and research needs in the field of application of LCA to neighborhood scale assessment are identified, such as the definition of the functional unit and the need for contextualization methodologies aligned with data availability at the design stages of a neighborhood development project.
However, as with every new technology, a number of methodological improvements and specific challenges need to be addressed.
This lack of formal blinding in trials is recognised as a methodological challenge 51 but need not be seen as a limitation because implementation of these findings would also necessarily be unblinded, so a pragmatic approach to studying these interventions can be relevant.
However, we faced two important methodological challenges, both of which indicate the need for further research.
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