Scientific and methodological challenges make it hard to evaluate links between climate change and human conflict.
Methodological challenges have limited the empirical investigation of these issues.
In order to move towards such integration, a series of methodological challenges have to be met.
Obtaining more precise rates of error is an enormous challenge, given the heterogeneous data and methodological and logistical challenges noted above.
Given these methodological challenges, it is clear that only by combining, often in an ad-hoc fashion, different sources of information can one probably get somewhat adequate or reasonable estimates of the "correct" duration and case fatality (CF) of various types of tuberculosis.
6 Nevertheless, given these methodological challenges, and pending evidence to the contrary, we believe that pulse rate should remain a routine part of the assessment of a febrile child, since it is quick and easy to elicit, helps to provide a more complete picture of the child's physiological state and facilitates monitoring of their clinical course.
Given the methodological challenges associated with ascertaining traditional clinical effectiveness data in the context of genetic diagnosis, a much-needed evidence base, reflecting on utility in the form of clinical action or altered medical recommendations is beginning to emerge in the pediatric context.
From a research perspective, it is not too surprising that adjusted hospital mortality is not related to MI in our study, given the methodological challenges that limit its use, mainly driven by the low signal to noise ratio and subsequent problems of risk adjustment, such as the case-mix adjustment fallacy or constant risk fallacy [ 28].
Evaluation of disaster health and health response interventions is faced with several methodological challenges.
All of these issues give rise to methodological challenges for adaptation processes.
