Another methodological challenge concerns the selection and use of appropriate comparison groups.
There are several methodological and ethical challenges concerning research in rare disorders; it is difficult to find samples of sufficient magnitude [ 28], and small sample sizes give challenges in relation to anonymity [ 29].
Some challenges concerning teamwork emerged.
We also point to new methodological challenges ahead, particularly concerning the incorporation of historical and institutional dimensions into interview-based studies.
The purpose of this study was to examine methodological challenges, in particular issues concerning completeness of external cause coding, determination of incident cases and the amount of relevant inpatient days, in using the Finnish National Hospital Discharge Register (FHDR) for studying fire-related injuries.
As in drug trials, the use of PROs in device evaluation has several methodological challenges, ranging from general concerns about interpretation, to more specific issues related to study design and regulatory approval (use of PROs as primary end points, incorporation in labeling, and product promotion).
Lastly, while the main concern of this paper is with methodological challenges, the high values of the ceiling ratios that we found for the CHBI scheme to be cost-effective are of interest.
The accurate measurement of violence in the community is beset by several methodological challenges such as reliance on self-report, or information being documented in police files concerning arrest or conviction.
Any empirical analysis that is concerned with the interdependence of outpatient and inpatient care faces two methodological challenges.
A number of prior analyses have discussed methodological challenges in describing the natural history of HPV disease [ 27, 29- 31], and several explicit choices concerning alternate data sources and study designs were made in the present review.
