Discordance, however, can arise through true biological phenomena or through methodological issues; the burden of proof for establishing discordance is more substantial.
Given the small size of the liver in young embryos and the low fungal burdens, methodological differences can easily influence detection of dissemination and might therefore explain the differing results.
The factors were: teachers' methodological deficiencies; academic over-burden; beliefs about performances; public interventions; negative social environment; exams; content worthlessness; and participation difficulties.
The topics for the interview schedule were derived from methodological (theoretical) benefits and burdens of n-of-1 trials, 24 published studies on experiences of patients and carers with n-of-1 trials, 33 35 and process-related aspects of the trial at hand.
However, nested RTs pose a number of methodological challenges, including increased management burden, preferences of people recruiting participants for one recruitment strategy over another, and the potential impact on the statistical power of the 'host' RT [ 26].
Of these 30 diseases, we exclude four diseases which are not included in GBD 2010, and for which we therefore lack comparable disease burden data (see methodological appendix, Supplementary file 1, for details).
However, the substantial methodological difficulties in estimating the burden of mortality directly attributable to mental illnesses, as well as the paucity of available data [ 2] means that these figures are likely to under-represent the full picture of mental disorders burden.
Three trials (two on back pain and one on enuresis) were judged to be burdened with serious methodological flaws.
Filicide being a comparatively rare event, the data of previous studies have commonly been limited, examined only as subgroups of filicide, or burdened with other methodological problems.
Availability is a well known factor for explaining variation in utilization rates for radiology [ 16, 17], and probably contributes to the high variability of MRI and CT examinations and the strikingly high rates in Oslo (although burdened with some methodological uncertainties) found in this study.
