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It should be noticed that methodological biases exist since the method relies on a reconstructed phylogeny based on extant copies, and only duplicative transposition are scored.
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Similarly, our analysis showed that the average EQ-5D index score of adult CF patients was significantly lower than in the general population, an indication that a methodological bias may exist in using the latter in economic analyses.
The issue is that these biases exist beyond our control.
Substantial methodological risks of bias existed across all studies in our animal sample, although we could not detect differences in risks of bias between the non-industry and industry sponsored studies.
Generally, different sources of bias exist.
Why would such a bias exist?
Several sources of potential bias exist.
However, in the assessment of an extremely subjective phenomenon, methodological bias cannot be ruled out.
Many methodological biases preclude conclusive information.
There were few patients and methodological biases were numerous.
Most of these studies were observational, with a small number of patients and methodological biases [116 120].
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