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There is currently no validated gold standard or single recommended instrument for methodological assessment of risk factor studies, so a combined methodological assessment was developed for this review and tailored to assess the specific areas of risk factor studies which were considered to be important.
Study methodological assessment was evaluated using the PEDro score.
A three-stage inclusion process consisting of initial sifting, checking full-text papers on inclusion criteria, and methodological assessment, was performed independently by two reviewers.
The methodological assessment was done by one researcher [PM] and 50% of the references were also checked independently by a second reviewer [AF, WD] (in this case the mean of the two scores was computed).
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Details of the methodological assessment are shown in Fig. 2.
Data extraction and methodological assessment were conducted by two reviewers independently.
The test threshold of presepsin of diagnosing sepsis ranged from 317 to 729 pg/ml.> -wrap-foot> intensivesive care unit, ED emergency department, PR prospective recruitment, CR consecutive recruitment, NA not available, ACCP/SCCM American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Details of the methodological assessment are shown in Fig. 2.
The search strategy was completed by MF, data extraction, analysis and methodological assessments were made by MF, DB and JS.
Bias in methodological quality assessment was minimized by the independent assessment of study quality by the two researchers (VA and AH).
Inter-assessor agreement of the methodological quality assessment was calculated using kappa scores [ 15].
Data extraction and thorough methodological quality assessment was undertaken by two reviewers independently.
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