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But the effects of the methodology and specifically the combined effect of choices relative to these methodological aspects have not been fully explored.
While the importance and difficulties of such models have been discussed by various authors during the past decade, mainly with a focus on how to describe or develop such models, several biological and methodological aspects have never been addressed so far, which are relevant for the application of models in risk assessment.
Assume that an evolutionary pipeline has been established, and all methodological aspects have been appropriately considered: does this merit publication?
Several methodological aspects have to be considered when a first-line therapy such as metformin is compared with second- or third-line therapies (Fig. 2).
Most likely, methodological aspects have had an effect on the magnitude of the effect seen in some studies, or on their likelihood to be published, but they are not solely responsible for study outcome.
Methodological aspects have been debated as well [ 12- 16] with particular focus on statistical adjustment procedures and on how minimum volumes effect the geographically equal access to care by causing centralisation of care [ 17- 21] as well as accessibility of providers from the patients' perspective [ 22].
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In the context of meta-analysis, the individual assessment of the various methodological aspects has been shown to be more informative with respect to their effect on effect size.
Our procedure implies some important methodological aspects that have to be kept in mind: The value of m = 10 has been selected by the condition that the final result displays a minimum error.
The interpretability of results of this study is limited by several methodological aspects which have to be mentioned.
This study and ours vary from each other with regard to some methodological aspects, which have to be considered: First, Gladdy et al (2010) restricted their analysis to non-metastatic soft-tissue sarcoma, whereas we also included bone sarcomas and patients with metastatic RIS.
To tackle this problem technical, methodological as well as communicative aspects have to be considered.
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