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Therefore, additional methodological approaches such as fluorescence lifetime imaging microscopy (FLIM) would be required.
Andresen et al 65 suggest methodological approaches such as aggregation, spatial smoothing, small area estimation and exact statistics.
Intriguing research questions and novel methodological approaches such as these might not have been posed in the absence of the present observations.
More recently, some interesting studies have been published with well-described methodological approaches, such as cluster randomization and theory-based interventions [ 13, 49- 52].
In the study of patient delay various methodological approaches such as interviews, [ 12- 14] and large surveys [ 4, 15] have been applied.
The mode of reproduction in samples with peak ratios exceeding this arbitrary threshold should be investigated using other methodological approaches such as dissecting techniques.
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Another reason which could be possible for the variation in the observed bone mineral density values is the difference in methodological approach such as the use of different slice thickness, software, CT machines, etc. [17].
This study conducted a qualitative case study methodological approach, such that secondary and primary case study literature was used to conduct case study comparisons of multilateral health agencies.
However, these data should be interpreted cautiously in the context of our present work since, although Tai et al. have indeed quantified bouton densities and sizes, their study on axonal structure was only qualitative and would benefit from a methodological approach such as the one we have developed here.
We agree from our experience and make a plea for continued work on methodological approaches in such settings.
However, we have also found a large fraction of non-overlapping deregulated miRNAs that might be explained with the different methodological approaches used, such as miRNA platforms, the bioinformatics and statistical methods employed to analyze data and particularly to identify diagnostic and prognostic signatures.
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