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We need a cautious, methodological approach with sound scientific evidence".

Since the energy refurbishment can be easily associated to structural consolidation or functional reorganization works, this paper is aimed to introduce a methodological approach with reference to both structural behavior and energy performance for the space heating and cooling.

These authors indeed applying a different methodological approach (with a blind procedure for both VEP recording and analysis) in a series of studies (exploring a wide range of stimulation parameters) were not able to replicate, at least for visual modality, the habituation defect and attributed this to a likely expectancy bias not adequately controlled in previous studies.

However, well-described models applying this methodological approach with different cell lines and various cell plasticity modulating conditions are missing.

For this analysis we combined parts of an established process analysis method by Pomberger and Gerken [ 33– 35] with semi-structured interviews, feedback loops and classification methods in a new methodological approach with 14 steps (Fig.  1).

It has to be noticed, however, that the results of the two studies generally are difficult to compare as we used a different methodological approach with open questions and no concrete PM-example astimulusus (the experts in [ 10] were asked explicitly about the implications of their own development, the Rectumchip).

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Internet research poses particular challenges to age verification, assent and consent procedures, and appropriate methodological approaches with minors.

This paper will provide general description of droughts in addition to the regional methodological approaches with rather simple but innovative manner.

The methodological approach, along with the empirical case studies used, is outlined in the fourth section.

It is a unique methodological approach, applicable with respect to both the law as applied in the Western world and going beyond state borders.

This is possibly due to the inability to transfect MCNs throughout the SON using this methodological approach, compared with the high transfection efficiencies achievable using in vitro systems.

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