The LONI Pipeline mediates these difficulties by providing clear, functional and complete record of the methodological and technological protocols for the analysis.
(5) Different methodological approaches and protocols for measuring LOX could account for some of the reported differences.
However, our meta-analysis also has many limitations, such as the clinical and methodological heterogeneity, protocol deviations, sparse data, and concerns regarding small trial bias.
EMG helped with the design of the study protocol and reviewed all methodological and statistical parts of the protocol.
We extracted data on trial characteristics; outcomes; methodological quality; reporting; and registration and protocol characteristics.
CdB provided expert methodological and clinical feedback to protocol and manuscript, providing methodological perspective and data analysis.
RECs frequently commented on inadequacies in informed consent forms, possible risks to participants, methodological and statistical issues in protocols, and missing or incorrect supporting documentation [ 5– 10].
Although a unique group of participants performed both studies, we employed the same methodological protocol and utilised the same environmental conditions (WBGT21, -30, and -37), work rates (2.5, 4, and 5.5 km·h−1), and termination criteria [ 28].
Overall, this protocol provides methodological and practical guidance for researchers wanting to study PBSP impacts on health.
PDS provided methodological and practical expertise to the protocol from his experience with the NHS cervical screening programme.
