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Methodologic quality is a construct defined as the confidence that the study design, conduct and analysis minimises bias[ 22] in the estimation of the association between test and outcome, thereby maintaining internal validity (i.e. the degree to which the results of this observation are correct for the patients being studied).
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Limitations in methodologic quality were noted in all studies.
Methodologic quality was assessed by using the Quality Assessment of Diagnostic Accuracy Studies tool.
Results supported by objective measures of physical activity and studies with higher methodologic quality were highlighted.
The median score of methodologic quality was 2.5 (interquartile range 2 4).
Methodologic quality was scored using criteria set out by Jadad et al. (16).
Methodologic quality was moderate (mean NOS score, 6.07; standard deviation, 0.49).
Of the 46 studies that were included, 31 used self-reported physical activity; average methodologic quality was 3.2 (scored), scored 0 5.
The methodologic quality was used as an additional criterion for inclusion, and studies had to be of high quality to be selected for final review.
A scale assessing methodologic quality was constructed (shown in Appendix A, available online at www.ajpm-online.net) and modified from previously reported checklists.
In the comparison of magnesium versus placebo, four studies with good methodologic quality were included [ 13- 16], and no significant differences could be found in ROSC, survival to admission, and survival to hospital discharge between the two treatments.
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